CYP3A4-IN-2

Names

[ CAS No. ]:
2562383-94-0

[ Name ]:
CYP3A4-IN-2

Biological Activity

[Description]:

CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) with the IC50 value of 0.055 μM. CYP3A4-IN-2 is a ritonavir analogue with increased hydrophobicity of the R2 side group and stronger inhibitory effect compared to ritonavir. CYP3A4-IN-2 can be used as an antiviral agent and immunosuppressants[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Inflammation/Immunology

[Target]

CYP3A4:0.055 μM (IC50)


[References]

[1]. Eric R Samuels, et al. An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4. Bioorg Med Chem. 2020 Mar 15;28(6):115349. doi: 10.1016/j.bmc.2020.115349. Epub 2020 Jan 31.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H38N4O3S

[ Molecular Weight ]:
570.74

Related Compounds