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KSK68

Names

[ CAS No. ]:
2566715-91-9

[ Name ]:
KSK68

Biological Activity

[Description]:

KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively. KSK68 has negligible affinity at the other histamine receptor subtypes. KSK68 can be used for research of nociceptive and neuropathic pain[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Sigma Receptor
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

7.7 nM, 3.6 nM、22.4 nM (H3 receptor, sigma-1, sigma-2 receptor)[1]


[References]

[1]. Szczepańska K, et al. Dual Piperidine-Based Histamine H3 and Sigma-1 Receptor Ligands in the Treatment of Nociceptive and Neuropathic Pain. J Med Chem. 2023 Jul 27;66(14):9658-9683.  

Chemical & Physical Properties

[ Molecular Formula ]:
C23H28N2O2

[ Molecular Weight ]:
364.48

Related Compounds