Cbl-b-IN-3

Names

[ Name ]:
Cbl-b-IN-3

Biological Activity

[Description]:

Cbl-b-IN-3 (Compound 23) is a casitas B-lineage lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC50 of < 1 nM. Cbl-b is an E3 ubiquitin ligase that negatively regulates T-cell activation[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme

[Target]

IC50: < 1 nM (Cbl-b)[1]

[In Vitro]

Cbl-b-IN-3 (Compound 23) enhances IL-2 secretion by T-cells stimulated with an anti-CD3 antibody alone or in combination with an anti-CD28 antibody[1].

[References]

[1]. Arthur T. Sands, et al. Substituted benzyl-triazole compounds for cbl-b inhibition, and further uses thereof. WO2020264398A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₃₄F₃N₅O

[ Molecular Weight ]:
537.62

Cbl-b-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds