PI3Kγ inhibitor 7

Names

[ CAS No. ]:
2575863-25-9

[ Name ]:
PI3Kγ inhibitor 7

Biological Activity

[Description]:

PI3Kγ inhibitor 7 (compound 2) is a potent and orally active PI3Kγ inhibitor with IC50 values of 4768, 878.1, 3.42, 355.2 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, respectively. PI3Kγ inhibitor 7 shows antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

PI3Kα:4768 nM (IC50)

PI3Kβ:878.1 nM (IC50)

PI3Kγ:3.42 nM (IC50)

PI3Kδ:355.2 nM (IC50)


[References]

[1]. HeJun Lv, et al. Alkyne derivative, preparation method for same, and uses thereof. WO2021004421A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H25N9O2

[ Molecular Weight ]:
555.59

Related Compounds