Dot1L-IN-7

Names

[ CAS No. ]:
2580940-76-5

[ Name ]:
Dot1L-IN-7

Biological Activity

[Description]:

Dot1L-IN-7 (compound 25) is a potent and selective disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 of 1.0 μM. Dot1L-IN-7 selectively killed Mixed Lineage Leukemia (MLL)-AF9 without showing any effect on the growth of E2A-HLF cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[Target]

DOT1L:1 μM (IC50)


[References]

[1]. Garrett S Gibbons, et al. Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library. Eur J Med Chem. 2020 Mar 1;189:112023.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H27N9O2

[ Molecular Weight ]:
461.52

Related Compounds