IEM 1925 dihydrobromide

IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy[1][2].

Signaling Pathways >> GPCR/G Protein >> mGluR

Research Areas >> Neurological Disease

IEM-1925 (10 mg/kg) 减弱了大鼠癫痫状态下的行为运动惊厥症状，将Pinel和Rovner评分中的癫痫发作强度从8分降至4分。 Animal Model: Rats (males, weight 240-350 g)[2]. Dosage: 5, 10 mg/kg. Administration: i.m. Result: Administration of 5 and 10 mg/kg IEM-1925 2 h before pilocarpine did not alter the overall SE pattern. However, IEM-1925 significantly changed the latent periods of onset and durations of the separate phases and also decreased the total duration of status.

[1]. D B Tikhonov, et al. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74.  

[2]. S. I. Vataev, et al. IEM-1925, a Glutamate Receptor Channel Blocker, Increases the Latent Period and Decreases the Duration of Status Epilepticus in Rats in a Lithium-Pilocarpine Model of Epilepsy. Neuroscience and Behavioral Physiology volume 51, pages976–984 (2021).