Robenidine hydrochloride
Names
[ CAS No. ]:
25875-50-7
[ Name ]:
Robenidine hydrochloride
[Synonym ]:
EINECS 247-307-8
MFCD01724404
Robenidine hydrochloride
Biological Activity
[Description]:
[Related Catalog]:
[Target]
MIC50: 8.1 μM (MRSA), 4.7 μM (VRE)[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
488.1ºC at 760 mmHg
[ Melting Point ]:
252-254°C
[ Molecular Formula ]:
C15H14Cl3N5
[ Molecular Weight ]:
370.664
[ Flash Point ]:
249ºC
[ Exact Mass ]:
369.031494
[ PSA ]:
72.63000
[ LogP ]:
5.15890
[ Vapour Pressure ]:
1.12E-09mmHg at 25°C
[ Storage condition ]:
0-6°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ME8651000
- CHEMICAL NAME :
- Guanidine, 1,3-bis((p-chlorobenzylidene)amino)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 25875-50-7
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C15-H13-Cl2-N5.Cl-H
- MOLECULAR WEIGHT :
- 370.69
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 21,794,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 23,724,1975
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22
[ RIDADR ]:
NONH for all modes of transport
[ RTECS ]:
ME8651000
Articles
Vet. Rec. 162(5) , 153-5, (2008)
The effect of subcutaneously injected diclazuril on the output of Eimeria species oocysts was studied in experimentally infected rabbits. Diclazuril was administered either prophylactically at 0.5, 1 ...
Use of antigen mimics to produce specific antibodies to anti-coccidial drugs.J. Immunol. Methods 323(1) , 31-8, (2007)
A range of polyclonal antibodies was successfully produced to the coccidiostatic drugs diclazuril and robenidine. Initial attempts to make immunogenic complexes of both drugs were ineffective due to d...
Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken.Res. Vet. Sci. 47(1) , 125-8, (1989)
Thirty isolates of Eimeria tenella obtained from broiler and breeder farms were examined for their sensitivity to anticoccidial drugs. All were sensitive to robenidine, 28 were sensitive to methyl ben...