(4,5,5,5,5',5',5'-2H7)Leucine

Names

[ CAS No. ]:
259225-40-6

[ Name ]:
(4,5,5,5,5',5',5'-2H7)Leucine

[Synonym ]:
Leucine-4,5,5,5,5',5',5'-d
(4,5,5,5,5',5',5'-H)Leucine

Biological Activity

[Description]:

(±)-Leucine-d7 is the deuterium labeled (±)-Leucine. (±)-Leucine (DL-Leucine), an isomer of Leucine, chemosterilant and dietary additive. (±)-Leucine inhibits growth of Escherichia coli HfrH by 92.08%[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Hendricks DE, et, al. Attractiveness of tobacco budworm females altered by oral chemosterilants and dietary additives. Journal of Chemical Ecology. 1977 Mar; 127-131.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
225.8±23.0 °C at 760 mmHg

[ Melting Point ]:
293-296ºC (subl.)(lit.)

[ Molecular Formula ]:
C6H6D7NO2

[ Molecular Weight ]:
138.22

[ Flash Point ]:
90.3±22.6 °C

[ Exact Mass ]:
138.138565

[ PSA ]:
63.32000

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.463

[ Storage condition ]:
-20C

Related Compounds