1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

Names

[ Name ]:
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

[Synonym ]:
N-(3-(Dimethylamino)propyl)-N'-ethylcarbodiimide hydrochloride
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride
Carbodiimide, (3-dimethylaminopropyl)ethyl-, monohydrochloride
EDC HCL
EDAC,Hydrochloride
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride
N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide hydrochloride
Carbodiimide, [3-(dimethylamino)propyl]ethyl-, hydrochloride
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride
1-Ethyl-3-[3-(dimethylamino)propyl]carbodiimide monohydrochloride
1-Ethyl-3-(3-dimethyllaminopropyl)carbodiimide hydrochloride
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Hydrochloride
N'-(Ethylcarbonimidoyl)-N,N-dimethyl-1,3-propanediamine hydrochloride
N-[3-(Dimethylamino)propyl]-N'-ethylcarbodiimide hydrochloride
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride
N-Ethyl-N'-[3-(dimethylamino)propyl]carbodiimide hydrochloride
1,3-Propanediamine, N-(ethylcarbonimidoyl)-N,N-dimethyl-, hydrochloride (1:1)
1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride
EDCI
1-ethyl-3(3-dimethylaminopropyl) carbodiimide hydrochloride
EINECS 217-579-2
Carbodiimide, [3-(dimethylamino)propyl]ethyl-, monohydrochloride
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, hydrochloride
1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Hydrochloride [Coupling Agent
EDAP
N-[3-(Dimethylamino)propyl]-N'-ethylcarbodiimide hydrochloride (1:1)
Carbodiimide, (3-(dimethylamino)propyl)ethyl-, monohydrochloride
Carbodiimide, (3-dimethylaminopropyl)ethyl-, hydrochloride
3-(3-Dimethylaminopropyl)-1-Ethylcarbodiimide Hydrochloride
MFCD00044916
1-(3-(dimethylamino)-propyl)-3-ethylcarbodiimide hydrochloride
N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine hydrochloride
EDC.HCl
EDC hydrochloride
edac hcl
wsc hcl
1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride
EDC·HCl
1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE,EDC.HCl

Biological Activity

[Description]:

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride is a carbodiimide reagent that can form nucleic acid and compounds with amide bonds. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride accelerates the formation reaction of esters, amides, and peptides, as a condensing and dehydrating agent, which are often used for polynucleotide synthesis, anhydroxydation, lactonization and esterification[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC.HCl) is a very useful agent to form amide bonds (peptide bonds) in an aqueous medium[1]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl), is widely used for polyaniline-carbon nanotube preparation for a cholesterol biosensor, precolumn derivatization of aliphatic amines for HPLC, molecular beacons formation for DNA reseach, sensor preparation for calcium detection, the fluorescent determination of carboxylic acids, and solidphase microsequencing of peptides[2]. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC•HCl) is an aminoaldehyde dehydrogenase (AMADH) inhibitor, while its inhibition on glutamate decarboxylase (GAD) is insignificant[3].

[References]

[1]. Kunihiko Seno, et al. Spectrophotometric determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow injection analysis. Anal Sci. 2008 Apr;24(4):505-8.

[2]. Kunihiko Seno, et al. Determination of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride by flow-injection analysis based on a specific condensation reaction between malonic acid and ethylenediamine. Anal Sci. 2009 Mar;25(3):389-93.

[3]. Runqiang Yang, et al. AMADH inhibitor optimization and its effects on GABA accumulation in soybean sprouts under NaCl-CaCl 2 treatment. 3 Biotech. 2019 May;9(5):184.

Chemical & Physical Properties

[ Density]:
0.877 g/mL at 20 °C(lit.)

[ Boiling Point ]:
269.1ºC at 760 mmHg

[ Melting Point ]:
110-115 °C(lit.)

[ Molecular Formula ]:
C₈H₁₈ClN₃

[ Molecular Weight ]:
191.70

[ Flash Point ]:
107.9ºC

[ Exact Mass ]:
191.118927

[ PSA ]:
27.96000

[ LogP ]:
1.93390

[ Vapour Pressure ]:
0.171mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.461

[ Storage condition ]:
−20°C

[ Stability ]:
Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture.

[ Water Solubility ]:
Soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S37/39

[ RIDADR ]:
UN 2735 8/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
FF2200000

[ HS Code ]:
29252000

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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