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H-Ile-Pro-Pro-OH

Names

[ CAS No. ]:
26001-32-1

[ Name ]:
H-Ile-Pro-Pro-OH

[Synonym ]:
isoleucyl-prolyl-proline
IPP,ACE-I Inhibitor
Ile-Pro-Pro

Biological Activity

[Description]:

H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[Target]

IC50: 5 μM (ACE)[2]


[In Vitro]

Vitro: Ile-Pro-Pro (IPP) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].

[In Vivo]

Vivo: Ile-Pro-Pro attenuates arterial dysfunction in L-NAME-treated rats[1] Ile-Pro-Pro (IPP) decreases blood pressure in spontaneously hypertensive rats (SHR) [1]. Ile-Pro-Pro (IPP) attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].

[References]

[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7.

[2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

Chemical & Physical Properties

[ Density]:
1.248 g/cm3

[ Boiling Point ]:
572.556ºC at 760 mmHg

[ Molecular Formula ]:
C16H27N3O4

[ Molecular Weight ]:
325.40

[ Flash Point ]:
300.071ºC

[ Exact Mass ]:
325.20000

[ PSA ]:
103.94000

[ LogP ]:
1.00250

Related Compounds