Rhodojaponin II

Names

[ Name ]:
Rhodojaponin II

[Synonym ]:
Grayanotoxane-5,6,10,14,16-pentol, 2,3-epoxy-, 6-acetate
Rhodojaponin-II
7,9a-Methano-9aH-cyclopenta(b)heptalene-4,8,11,11a,12(1H)-pentol,2,3-epoxydodecahydro-1,1,4,8-tetramethyl-,11-acetate,(2R,3S,3as,4R,4ar,7R,8R,9as,11R,11aR,12R)
5,10,14,16-Tetrahydroxy-2,3-epoxygrayanotoxan-6-yl acetate

Biological Activity

[Description]:

Rhodojaponin II is a diterpenoid from the leaves of Rhododendron molle with anti-inflammatory activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Zhou J, et al. Anti-inflammatory Grayanane Diterpenoids from the Leaves of Rhododendron molle. J Nat Prod. 2018 Jan 26;81(1):151-161.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
569.4±50.0 °C at 760 mmHg

[ Melting Point ]:
294.5-296 °C

[ Molecular Formula ]:
C₂₂H₃₄O₇

[ Molecular Weight ]:
410.501

[ Flash Point ]:
194.6±23.6 °C

[ Exact Mass ]:
410.230438

[ PSA ]:
119.75000

[ LogP ]:
0.56

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.603

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB9235000

CHEMICAL NAME :: 7,9a-Methano-9aH-cyclopenta(b)heptalene-4,8,11,11a,12 (1H)-pentol, 2,3-epoxydodecahydro-1,1, 4,8-tetramethyl-, 11-acetate, (2R,3S,3as,4R,4ar,7R,8R,9as,11R,11aR,12R)-

CAS REGISTRY NUMBER :: 26116-89-2

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H34-O7

MOLECULAR WEIGHT :: 410.56

WISWESSER LINE NOTATION :: T G3 E5 B765 A 1B Q BX HOTJ AQ DOV1 DQ F1 F1 KQ K1 PQ P1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 35,303,1976