hexaethyleneglycol

Names

[ Name ]:
hexaethyleneglycol

[Synonym ]:
EINECS 220-045-1
HEXAETHYLENE GLYCOL
Polyethylene glycol 300
MFCD00002877
3,6,9,12,15-Pentaoxaheptadecane-1,17-diol
hexa-PEG-diol
2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
hexaethyleneglycol
PEG-6
Hexagol
Hexaoxyethylene glycol

Biological Activity

[Description]:

Hexaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
378.3±0.0 °C at 760 mmHg

[ Melting Point ]:
5-7 °C(lit.)

[ Molecular Formula ]:
C₁₂H₂₆O₇

[ Molecular Weight ]:
282.331

[ Flash Point ]:
193.7±26.5 °C

[ Exact Mass ]:
282.167847

[ PSA ]:
86.61000

[ LogP ]:
-2.95

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.460

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MM3670000

CHEMICAL NAME :: Hexaethylene glycol

CAS REGISTRY NUMBER :: 2615-15-8

BEILSTEIN REFERENCE NO. :: 1638281

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H26-O7

MOLECULAR WEIGHT :: 282.38

WISWESSER LINE NOTATION :: Q2/O2/ 5Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

REFERENCE :: JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
MM3670000

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Synthesis and evaluation of new spacers for use as dsDNA end-caps.

Bioconjug. Chem. 21(8) , 1545-53, (2010)

A series of aliphatic and aromatic spacer molecules designed to cap the ends of DNA duplexes have been synthesized. The spacers were converted into dimethoxytrityl-protected phosphoramidites as syntho...

Adsorption isotherms of aqueous C12E6 and cetyltrimethylammonium bromide surfactants on solid surfaces in the presence of low molecular weight coadsorbents.

Langmuir 25(10) , 5536-44, (2009)

In this work, we evaluate the effects of the low molecular weight compounds toluene, phenol, and 1-hexanol on the adsorption of two surfactants on one solid surface. The surfactants are cetyltrimethyl...

A nicked duplex decamer DNA with a PEG(6) tether.

Nucleic Acids Res. 29(5) , 1132-43, (2001)

A dumbbell double-stranded DNA decamer tethered with a hexaethylene glycol linker moiety (DDSDPEG), with a nick in the centre of one strand, has been synthesised. The standard NMR methods, E.COSY, TOC...