Denudatine

Names

[ Name ]:
Denudatine

[Synonym ]:
(7α,11β,15β,20R)-21-Ethyl-4-methyl-7,20-cycloatid-16-ene-11,15-diol
(7α,11β,15β)-21-Ethyl-4-methyl-7,20-cycloatid-16-ene-11,15-diol
16,17-Didehydro-21-ethyl-4-methyl-7,20-cycloatidane-11-β,15-β-diol

Biological Activity

[Description]:

Denudatine, is primarily isolated from plants of the genera Aconitum and Delphinium[1]. Denudatine has effects on action potential of ventricular fibers and inhibits arrhythmogenic action of aconitine[2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Nishiyama Y, et al. Synthesis of Cardiopetaline via a Wagner-Meerwein Rearrangement without Preactivation of the Pivotal Hydroxy Group. Org Lett. 2017 Nov 3;19(21):5833-5835.

[2]. Liu TF, et al. Effects of denudatine on action potential of ventricular fibers and its inhibition on arrhythmogenic action of aconitine (author's transl). Zhongguo Yao Li Xue Bao. 1982 Mar;3(1):32-4.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
488.2±45.0 °C at 760 mmHg

[ Melting Point ]:
248-249℃

[ Molecular Formula ]:
C₂₂H₃₃NO₂

[ Molecular Weight ]:
343.503

[ Flash Point ]:
242.3±27.4 °C

[ Exact Mass ]:
343.251129

[ PSA ]:
43.70000

[ LogP ]:
3.07

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.620

[ Storage condition ]:
2-8C