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15-Acetoxyscirpenol

Names

[ CAS No. ]:
2623-22-5

[ Name ]:
15-Acetoxyscirpenol

[Synonym ]:
15-MONOACETOXYSCIRPENOL
deacetylanguidin
15-MONOACETYLSCIRPENOL
15-ACETOXYSCIRPENOL
15-Acetoxyscirpen-3,4-diol
monoacetoxyscirpenol
15-Acetoxyscirpenol
Desacetylanguidine
15-acetoxyscirpendiol
15-mas

Biological Activity

[Description]:

15-acetoxyscirpenol, one of acetoxyscirpenol moiety mycotoxins (ASMs), strongly induces apoptosis and inhibits Jurkat T cell growth in a dose-dependent manner by activating other caspases independent of caspase-3[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Others
Signaling Pathways >> Apoptosis >> Caspase

[Target]

Caspase


[References]

[1]. Lee DH, et al. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54.

Chemical & Physical Properties

[ Density]:
1.34g/cm3

[ Boiling Point ]:
465.5ºC at 760mmHg

[ Melting Point ]:
170-172 °C

[ Molecular Formula ]:
C17H24O5

[ Molecular Weight ]:
324.36900

[ Flash Point ]:
167.3ºC

[ Exact Mass ]:
324.15700

[ PSA ]:
88.52000

[ LogP ]:
0.55410

[ Vapour Pressure ]:
1.27E-10mmHg at 25°C

[ Index of Refraction ]:
1.584

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YD0111000
CHEMICAL NAME :
Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15-acetate
CAS REGISTRY NUMBER :
2623-22-5
LAST UPDATED :
198709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H24-O6
MOLECULAR WEIGHT :
324.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
725 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

Safety Information

[ Hazard Codes ]:
T+

[ Risk Phrases ]:
R25

[ RIDADR ]:
UN 2811 6.1/PG 3

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds