Acetaminophen Acetate (Acetaminophen Impurity)

Names

[ Name ]:
Acetaminophen Acetate (Acetaminophen Impurity)

[Synonym ]:
4-Acetamidophenyl acetate
Acetaminophen Acetate (Acetaminophen Impurity)
Acetaminophen acetate
EINECS 220-077-6
4-AcNHC6H4OAc
4'-Acetoxyacetanilide
Diacetamat
P-ACETOXYACETANILIDE
Acetaminophen Related Compound A
MFCD00059205
N,O-Diacetyl-4-aminophenol
4-(Acetylamino)phenyl acetate,p-Acetoxyacetanilide
4-Acetoxyacetanilide
Acetamide, N-[4-(acetyloxy)phenyl]-
diacetamate

Biological Activity

[Description]:

4-Acetamidophenyl acetate is an impurity of Acetaminophen (paracetamol). Acetaminophen, an analgesic drug, is a selective COX-2 inhibitor (IC50=25.8 μM), and is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.

[2]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
376.4±25.0 °C at 760 mmHg

[ Melting Point ]:
155°C

[ Molecular Formula ]:
C₁₀H₁₁NO₃

[ Molecular Weight ]:
193.199

[ Flash Point ]:
181.4±23.2 °C

[ Exact Mass ]:
193.073898

[ PSA ]:
55.40000

[ LogP ]:
0.60

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.561

[ Storage condition ]:
Refrigerator

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Analysis of tablets containing aspirin, acetaminophen, and ascorbic acid by high-performance liquid chromatography.

J. Pharm. Sci. 73(12) , 1830-3, (1984)

The high-performance liquid chromatographic method described enables the quantitation of the components and the main impurities of tablets containing aspirin, acetaminophen, and ascorbic acid. A C8 re...

[N,O-diacetyl-p-aminophenol formation by combined use of aspirin with phenacetin and acetaminophen in vivo (author's transl)].

Yakugaku Zasshi 100(10) , 1043-7, (1980)