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ARD-2051

Names

[ CAS No. ]:
2632305-17-8

[ Name ]:
ARD-2051

Biological Activity

[Description]:

ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 can be used for the research of prostate cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC
Signaling Pathways >> Others >> Androgen Receptor

[Target]

DC50: 0.6 nM (AR protein degradation)[1]


[References]

[1]. Han X, et al. Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2023 Jul 13;66(13):8822-8843.  

Chemical & Physical Properties

[ Molecular Formula ]:
C43H45ClN8O5

[ Molecular Weight ]:
789.32

Related Compounds