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CB2R probe 1

Names

[ CAS No. ]:
2634714-79-5

[ Name ]:
CB2R probe 1

Biological Activity

[Description]:

CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an Ki of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

cannabinoid type-2 receptors:130 nM (Ki)


[In Vitro]

CB2R probe 1 (compound 28) (100 nM; 24 h) shows low cytotoxicity with IC50s of 1.6, 1.4, 1.4, 1.1, 2.6, 0.55, 2.0, 2.4, 2.8 nM for PANC1, U2OS, HT29, HT29-DX, U87AD, PC3, CB2R-HEK293, MCF7, MCFT-DX cells, respectively[1].

[References]

[1]. Spinelli F, et al. Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R). Eur J Med Chem. 2020 Feb 15;188:112037.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H42N4O4

[ Molecular Weight ]:
594.74

Related Compounds