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MAK683-CH2CH2COOH

Names

[ CAS No. ]:
2639882-68-9

[ Name ]:
MAK683-CH2CH2COOH

Biological Activity

[Description]:

MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design PROTAC EED degrader-1 (HY-130614) and PROTAC EED degrader-2 (HY-130615)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[In Vitro]

MAK683-CH2CH2COOH inhibits Karpas422 cells with a GI50 of 14 nM for 14 days treatment[1].

[References]

[1]. Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii: S2451-9456(19)30362-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H21FN6O3

[ Molecular Weight ]:
448.45

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds