LRRK2-IN-3

Names

[ Name ]:
LRRK2-IN-3

Biological Activity

[Description]:

LRRK2-IN-3 (compoubd 24) is a potent, selective, orally active and brain-penetrant inhibitor LRRK2, with IC50 of 2.6 nM in human PBMCs. LRRK2-IN-3 can be used for the research of Parkinson's disease[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> LRRK2

Research Areas >> Neurological Disease

[Target]

IC50: 2.6 nM (hPBMCs LRRK2)[1]

[References]

[1]. Keylor MH, et, al. Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors. J Med Chem. 2022 Jan 13;65(1):838-856.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₉ClF₂N₆O₂

[ Molecular Weight ]:
518.99

LRRK2-IN-3

Names

Biological Activity

Chemical & Physical Properties

Related Compounds