Mtb ATP synthase-IN-1

Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium[1].

Research Areas >> Infection

Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase

Signaling Pathways >> Anti-infection >> Bacterial

MIC: 0.452-0.499 μg/mL (Mtb)[1]

Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability[1]. Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse[1]. PO (50 mg/kg) IV (5 mg/kg) Cmax (ng/mL) 1333 1241 Tmax (h) 0.83 T1/2 (h) 0.51 0.33 AUC0-t (ng/mL·h) 2197 1667 AUC0-∞ (ng/mL·h) 2198 1672 MRT0-∞ (ng/mL) 1.36 0.28 CL (mL/min/kg) 51.4 F (%) 13.1 Animal Model: Male CD-1 mouse[1] Dosage: 50 and 5 mg/kg Administration: 50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis) Result: Exhibited good metabolic stability and acceptable oral bioavailability.

[1]. Li P, et al. Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis. Eur J Med Chem. 2020;206:112538.