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6-Deoxyisojacareubin

Names

[ CAS No. ]:
26486-92-0

[ Name ]:
6-Deoxyisojacareubin

[Synonym ]:
6-deoxyjacareubin
6-deoxyjacreubin
6,11-Dihydroxy-3,3-dimethyl-3H-4,12-dioxa-benzo[a]anthracen-7-one
6,11-dihydroxy-3,3-dimethylpyrano[2,3-c]xanthen-7(3H)-one
6-Deoxyisojacareubin
6,11-dihydroxy-3,3-dimethyl-3H,7H-pyrano[2,3-c]-xanthen-7-one

Biological Activity

[Description]:

6-Deoxyisojacareubin is a PKC inhibitor that inhibits the proliferation of QGY-7703 cells in a concentration-dependent manner. 6-Deoxyisojacareubin is also a natural product that can be obtained from Garcinia nervosa. 6-Deoxyisojacareubin can be used in cancer research[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC
Research Areas >> Cancer
Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Dai M, Yuan X, Zhu ZJ, Shan L, Liu RH, Sun QY, Zhang WD. Efficient total synthesis and biological activities of 6-deoxyisojacareubin. Arch Pharm (Weinheim). 2013 Apr;346(4):314-20.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14O5

[ Molecular Weight ]:
310.30

[ Exact Mass ]:
310.08400

[ PSA ]:
79.90000

[ LogP ]:
3.54160

[ Storage condition ]:
2-8℃

Related Compounds