PD-1/PD-L1-IN-18

Names

[ CAS No. ]:
2648851-27-6

[ Name ]:
PD-1/PD-L1-IN-18

Biological Activity

[Description]:

PD-1/PD-L1-IN-18 (Compound L31) is a small-molecule inhibitor of the PD-1/PD-L1 protein-protein interaction. PD-1/PD-L1-IN-18 blocks PD-1/PD-L1 with the IC50 of 1.054 μM. Antitumor Activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[References]

[1]. Liu Liu, et al. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[ c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity. J Med Chem. 2021 Jun 24;64(12):8391-8409.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H32BrCl2N3O4

[ Molecular Weight ]:
685.43

Related Compounds