Eciskafusp alfa

Names

[ CAS No. ]:
2649758-52-9

[ Name ]:
Eciskafusp alfa

Biological Activity

[Description]:

Eciskafusp alfa is a programmed cell death 1 (PDCD1, best known as PD-1) cis-targeted IL2v immunocytokine. Eciskafusp alfa preferentially targets antigen-specific stem-like PD-1+ TCF-1+ CD8+ T cells and differentiates them towards a novel population of better effectors. Eciskafusp alfa can be used for the research of cancer and chronic infections[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[References]

[1]. Codarri Deak L, et al. Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition. Oncoimmunology. 2023 Mar 30;12(1):2197360.  

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds