KRAS G12C inhibitor 18

Names

[ CAS No. ]:
2649788-45-2

[ Name ]:
KRAS G12C inhibitor 18

Biological Activity

[Description]:

KRAS G12C inhibitor 18 is a potent and orally active KRAS G12C inhibitor. Anti-tumor activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C

[In Vitro]

KRAS G12C inhibitor 18 (compound 34) inhibits the growth of many KRas G12C mutant tumor cell lines (such as H358, SW1436, MiaPaca-2 cells, etc.)[1].

[In Vivo]

KRAS G12C inhibitor 18 exhibits a dose dependent inhibiton of pERK and active KRas after a single dose treatment from 12.5 to 100 mg/kg at 8 hours[1]. KRAS G12C inhibitor 18 (30 mg/kg; p.o.; twice daily) exhibits anti-tumor growth activity in lung cancer H358 xenograft mouse model[1].

[References]

[1]. Serge Louis Boulet, et al. Kras g12c inhibitors. WO2021118877A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₀ClFN₄O₃S

[ Molecular Weight ]:
510.97

KRAS G12C inhibitor 18

Names

Biological Activity

Chemical & Physical Properties

Related Compounds