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UR-8880

Names

[ CAS No. ]:
265114-23-6

[ Name ]:
UR-8880

[Synonym ]:
4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)imidazol-1-yl]benzenesulfonamide
UR-8880
Cimicoxib

Biological Activity

[Description]:

Cimicoxib (CX) is an orally active potent and selective COX-2 (cyclo-oxygenase-2) inhibitor. Cimicoxib exhibits promising anti-inflammatory and analgesic activity. The PK parameters of Cimicoxib in dogs given precise (2 mg/kg) and approximate doses (1.95-2.5 mg/kg) are similar[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2


[References]

[1]. Kim TW, Lebkowska-Wieruszewska B, Owen H, Yun HI, Kowalski CJ, Giorgi M. Pharmacokinetic profiles of the novel COX-2 selective inhibitor cimicoxib in dogs. Vet J. 2014 Apr;200(1):77-81.

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Boiling Point ]:
593.1ºC at 760 mmHg

[ Molecular Formula ]:
C16H13ClFN3O3S

[ Molecular Weight ]:
381.81

[ Flash Point ]:
312.5ºC

[ Exact Mass ]:
381.03500

[ PSA ]:
95.59000

[ LogP ]:
4.76890

[ Vapour Pressure ]:
4.91E-14mmHg at 25°C

[ Index of Refraction ]:
1.649

Related Compounds