NLRP3-IN-25

Names

[ CAS No. ]:
2660230-90-8

[ Name ]:
NLRP3-IN-25

Biological Activity

[Description]:

NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Interleukin Related
Signaling Pathways >> Immunology/Inflammation >> NOD-like Receptor (NLR)
Research Areas >> Inflammation/Immunology

[References]

[1]. Ohba Y et al. Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide[J]. ACS Medicinal Chemistry Letters, 2023.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19F3N4O5S

[ Molecular Weight ]:
448.42

Related Compounds