Medrysone

Names

[ CAS No. ]:
2668-66-8

[ Name ]:
Medrysone

[Synonym ]:
medrysone

Biological Activity

[Description]:

Medrysone is a corticosteroid, in ophthalmology for the treatment of eye inflammations.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
492.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₃₂O₃

[ Molecular Weight ]:
344.48800

[ Flash Point ]:
265.7ºC

[ Exact Mass ]:
344.23500

[ PSA ]:
54.37000

[ LogP ]:
3.94030

[ Vapour Pressure ]:
9.3E-12mmHg at 25°C

[ Index of Refraction ]:
1.552

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5250000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 11-beta-hydroxy-6-alpha-methyl-

CAS REGISTRY NUMBER :: 2668-66-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H32-O3

MOLECULAR WEIGHT :: 344.54

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 CQ E1 FV1 L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 338 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3713 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 711 (estimated) No. of Female Employees: 328 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TU5250000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Ocular pemphigus.

J. Egypt. Med. Assoc. 61(7-8) , 511-22, (1978)

Efficacy of medrysone as anti-inflammatory agent.

Indian J. Ophthalmol. 33(5) , 295-7, (1985)

Management of vernal conjunctivitis with steroid induced glaucoma--a comparative study.

Indian J. Ophthalmol. 35(5-6) , 298-301, (1987)