LUNA18

Names

[ CAS No. ]:
2676177-63-0

[ Name ]:
LUNA18

Biological Activity

[Description]:

LUNA18 is an orally active KRAS inhibitor with an IC50 of ＜2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

IC50: ＜2 nM (KRASG12D-SOS)[1] 0.043 nM (KRASG12D)[1]


[References]

[1]. Tanada M, et al. Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620.

Chemical & Physical Properties

[ Molecular Formula ]:
C73H105F5N12O12

[ Molecular Weight ]:
1437.68

Related Compounds