Trk-IN-10
Names
[ CAS No. ]:
2700265-61-6
[ Name ]:
Trk-IN-10
Biological Activity
[Description]:
Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key drug target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity[1].
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C20H20FN5O3
[ Molecular Weight ]:
397.40