EGFR-IN-36

Names

[ Name ]:
EGFR-IN-36

Biological Activity

[Description]:

EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR (WT):19.09 nM (IC50)

HER2(WT):120.01 nM (IC50)

HER2 (A775_G776insYVMA):2.35 nM (IC50)

[In Vitro]

EGFR-IN-36 (compound 8) inhibits A431 cell (IC50=223.6 nM),A549 cell (IC50=7644.42 nM), H1975 cell (IC50=20.68 nM)[1].

[References]

[1]. Yihan Wang, et al. Substituted acrylamide derivatives and their compositions and uses. WO2021185348A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅ClN₆O₂

[ Molecular Weight ]:
488.97

EGFR-IN-36

Names

Biological Activity

Chemical & Physical Properties

Related Compounds