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CHD1Li 6.11

Names

[ CAS No. ]:
2716890-91-2

[ Name ]:
CHD1Li 6.11

Biological Activity

[Description]:

CHD1Li 6.11 is a potent oncogenic CHD1L inhibitor (IC50=3.3 µM for cat-CHD1L recombinant protein). CHD1Li 6.11 is an orally bioavailable antitumor agent, significantly reducing the tumor volume of CRC xenografts generated from isolated quasi mesenchymal cells (M-phenotype), which possess enhanced tumorigenic properties[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Prigaro BJ, et al. Design, Synthesis, and Biological Evaluation of the First Inhibitors of Oncogenic CHD1L. J Med Chem. 2022;65(5):3943-3961.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H22BrN5OS

[ Molecular Weight ]:
472.40

Related Compounds