COX-2-IN-32

Names

[ Name ]:
COX-2-IN-32

Biological Activity

[Description]:

COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM)[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2

[References]

[1]. Emam SH, et al. Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells. Bioorg Chem. 2021 Feb;107:104630.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₄O₆

[ Molecular Weight ]:
420.45

COX-2-IN-32

Names

Biological Activity

Chemical & Physical Properties

Related Compounds