Nrf2 activator-6

Names

[ CAS No. ]:
2728780-74-1

[ Name ]:
Nrf2 activator-6

Biological Activity

[Description]:

Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4)[1].

[Related Catalog]:

Signaling Pathways >> NF-κB >> Keap1-Nrf2
Research Areas >> Cardiovascular Disease

[In Vitro]

Nrf2 activator-6 (Example 4) 增加 NRF2 介导的基因 NADPH：醌受体氧化还原酶 1 (NQO1) 的 mRNA 水平，EC50 为 0.3 nM[1]。

[References]

[1]. Cathy Louise LUCAS, et al. Tetrahydroisoquinoline compounds as nrf2 activators. WO2021214470A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H37ClFN5O5

[ Molecular Weight ]:
614.11

Related Compounds