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Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

Names

[ CAS No. ]:
2730-82-7

[ Name ]:
Acetamide,N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

[Synonym ]:
1-Formylcolchicin
4-Formylcolchicine

Biological Activity

[Description]:

4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

4-Formylcolchicine (compound 7) (0-5 µM; 24 h) shows antiproliferative activity with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1]. Cell Viability Assay[1] Cell Line: A549, HT-29, HCT116 cells Concentration: 0-5 µM Incubation Time: 24 h Result: Inhibited cell growth with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively.

[References]

[1]. Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2(5):348-52.

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
786.9ºC at 760mmHg

[ Molecular Formula ]:
C23H25NO7

[ Molecular Weight ]:
427.44700

[ Flash Point ]:
429.7ºC

[ Exact Mass ]:
427.16300

[ PSA ]:
100.16000

[ LogP ]:
3.07500

[ Vapour Pressure ]:
9.93E-25mmHg at 25°C

[ Index of Refraction ]:
1.589

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream