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SHP2 protein degrader-2

Names

[ CAS No. ]:
2740582-16-3

[ Name ]:
SHP2 protein degrader-2

Biological Activity

[Description]:

SHP2 protein degrader-2 (SHP2-D26) is a SHP2 protein PROTAC degrader. SHP2 protein degrader-2 reduces expression level of SHP2 in various cancer cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Signaling Pathways >> PROTAC >> PROTAC

[In Vitro]

SHP2 protein degrader-2 (SHP2-D26) achieves excellent degradation of SHP2 with the DC50 (the concentration where 50% of the protein has been degraded) values of 2.6 nM and 6.0 nM for MV4;11 and KYSE520 cells, respectively[1].

[References]

[1]. Song Y, et al. Strategies Targeting Protein Tyrosine Phosphatase SHP2 for Cancer Therapy. J Med Chem. 2022 Feb 24;65(4):3066-3079.

Chemical & Physical Properties

[ Molecular Formula ]:
C56H79ClN12O6S2

[ Molecular Weight ]:
1115.89

Related Compounds