m-PEG10-alcohol

Names

[ Name ]:
m-PEG10-alcohol

[Synonym ]:
O-methyl-decaethylene glycol
O-Methyl-decaaethylenglykol
2,5,8,11,14,17,20,23,26,29-Decaoxahentriacontan-31-ol
Decaethylene Glycol Monomethyl Ether

Biological Activity

[Description]:

m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Nnochiri Ekwuribe, et al. Calcitonin drug-oligomer conjugates, and uses thereof. US20040091452A1.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
524.3±45.0 °C at 760 mmHg

[ Melting Point ]:
19ºC

[ Molecular Formula ]:
C₂₁H₄₄O₁₁

[ Molecular Weight ]:
472.568

[ Flash Point ]:
270.9±28.7 °C

[ Exact Mass ]:
472.288361

[ PSA ]:
112.53000

[ LogP ]:
-4.02

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.455

MSDS

Click to get detail MSDS

Safety Information

[ HS Code ]:
2909499000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2909499000

[ Summary ]:
2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%