4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo-

Names

[ Name ]:
4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo-

[Synonym ]:
5-(2-furylmethylene)-2-thioxo-1,3-dihydropyrimidine-4,6-dione
5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
5-furan-2-ylmethylene-2-thioxodihydropyrimidine-4,6-dione
5-furfurylidene-2-thio-barbituric acid
5-Furfuryliden-2-thio-barbitursaeure
5-furfurylidene-2-thioxo-dihydro-pyrimidine-4,6-dione
5-(furan-2'-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

Biological Activity

[Description]:

CD00509 is a Tdp1 inhibitor, with an IC50 value of 0.71 μM. CD00509 can sensitize breast cancer cells to Camptothecin (HY-16560). CD00509 has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)

[References]

[1]. Laev SS, et al. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential. Bioorg Med Chem. 2016 Nov 1;24(21):5017-5027.

Chemical & Physical Properties

[ Density]:
1.54g/cm3

[ Molecular Formula ]:
C₉H₆N₂O₃S

[ Molecular Weight ]:
222.22

[ Exact Mass ]:
222.01000

[ PSA ]:
103.43000

[ LogP ]:
0.85150

[ Index of Refraction ]:
1.685

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%