TNIK-IN-4

Names

[ CAS No. ]:
2754266-04-9

[ Name ]:
TNIK-IN-4

Biological Activity

[Description]:

TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 0.61 μM (TNIK)[1]


[In Vitro]

TNIK-IN-4 (compound 5a) (0.4-100 μM; 72 hours) has inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM[1]. Cell Proliferation Assay Cell Line: HCT116 cells[1] Concentration: 0.4, 1.2, 3.7, 11.1, 33.3 and 100 μM Incubation Time: 72 hours Result: Showed inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM.

[References]

[1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H16FN3O3

[ Molecular Weight ]:
365.36

Related Compounds