TNG908

Names

[ Name ]:
TNG908

Biological Activity

[Description]:

TNG908 is a MTAP-cooperative PRMT5 inhibitor that can pass through the blood-brain barrier. TNG908 is 15 times more selective for MTAP null cell lines than MTAPWT cell lines, and can be used in cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[References]

[1]. K. Briggs, et al. TNG908 is a brain-penetrant, MTA-cooperative PRMT5 inhibitor for the treatment of MTAP-deleted cancer.MOLECULAR TARGETED AGENTS 2| VOLUME 174, SUPPLEMENT 1, S84, OCTOBER 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₃N₅O₂S

[ Molecular Weight ]:
409.50