PD-1/PD-L1-IN-32

Names

[ CAS No. ]:
2765535-21-3

[ Name ]:
PD-1/PD-L1-IN-32

Biological Activity

[Description]:

PD-1/PD-L1-IN-32 (compound A56) is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. PD-1/PD-L1-IN-32 significantly inhibits tumor growth in hPD-L1 MC38 humanized mouse model, without obvious toxicity against mouse normal ability[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[Target]

IC50: 2.4 nM (PD-1/PD-L1)[1]


[References]

[1]. Zhang H, et al. Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors. J Med Chem. 2023 Aug 10;66(15):10579-10603.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H25ClFN3O3

[ Molecular Weight ]:
517.98

Related Compounds