PHD2-IN-1

Names

[ CAS No. ]:
2768219-28-7

[ Name ]:
PHD2-IN-1

Biological Activity

[Description]:

PHD2-IN-1 is a potent and orally active inhibitor of HIF prolyl hydroxylase 2 (PHD2) with an IC50 of 22.53 nM. PHD2-IN-1 can be used for anemia research[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[References]

[1]. Wu Y, et.al. Preferred Conformation-Guided Discovery of Potent and Orally Active HIF Prolyl Hydroxylase 2 Inhibitors for the Treatment of Anemia. J Med Chem. 2023 Jul 13;66(13):8545-8563.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H23ClN4O5

[ Molecular Weight ]:
446.88

Related Compounds