EGFR mutant-IN-2

Names

[ CAS No. ]:
2770009-06-6

[ Name ]:
EGFR mutant-IN-2

Biological Activity

[Description]:

EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFRdel19/T790M/C797S mutant with an IC50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[References]

[1]. Dong H, et al. Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC. J Med Chem. 2023 May 25;66(10):6849-6868.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H27F3N6O2S

[ Molecular Weight ]:
556.60

Related Compounds