PROTAC α-synuclein degrader 5

Names

[ CAS No. ]:
2781922-42-5

[ Name ]:
PROTAC α-synuclein degrader 5

Biological Activity

[Description]:

PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research[1].

[Related Catalog]:

Signaling Pathways >> PROTAC >> PROTAC
Research Areas >> Neurological Disease

[References]

[1]. Yichen Tong, et.al. Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates. Journal of Medicinal Chemistry 2023 66 (12), 7926-7942

Chemical & Physical Properties

[ Molecular Formula ]:
C39H41N7O10

[ Molecular Weight ]:
767.78

Related Compounds