2,5-Dimethoxybenzoic acid

Names

[ Name ]:
2,5-Dimethoxybenzoic acid

[Synonym ]:
2,5-Dimethoxybenzoic acid
2,5-Dimethoxy-benzoesaeure
gentisic acid dimethyl ether
Dimethylaethergentisinsaeure
Benzoic acid, 2,5-dimethoxy-
6-Methoxy-m-anisic acid
MFCD00002436
2,5-dimethoxy-benzoic acid
2,5-bis-methoxybenzoic acid
EINECS 220-503-0
2,5-dimethoxylbenzoic acid
Benzoic acid,2,5-dimethoxy

Biological Activity

[Description]:

2,5-Dimethoxybenzoic acid is an intermediate used in the synthesis of the galbulimima alkaloid GB 13[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Mander LN, et al. The total synthesis of the Galbulimima alkaloid GB 13. J Am Chem Soc. 2003;125(9):2400-2401.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
329.5±22.0 °C at 760 mmHg

[ Melting Point ]:
74-78 °C

[ Molecular Formula ]:
C₉H₁₀O₄

[ Molecular Weight ]:
182.173

[ Flash Point ]:
133.6±15.8 °C

[ Exact Mass ]:
182.057907

[ PSA ]:
55.76000

[ LogP ]:
1.67

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.533

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

The total synthesis of the Galbulimima alkaloid GB 13.

J. Am. Chem. Soc. 125(9) , 2400-1, (2003)

This contribution describes a synthetic approach to alkaloid GB 13, previously isolated from the North Australian and Papua New Guinean rain forest tree Galbulimima belgraveana. A Birch reductive alky...

Reductive alkylation of 2, 5-dimethoxybenzoic acid: a direct synthesis of dihydrofluoren-2-ones. Hook JM and Mander LN.

J. Org. Chem. 45(9) , 1722-24, (1980)