GW4064
Names
[ CAS No. ]:
278779-30-9
[ Name ]:
GW4064
[Synonym ]:
GW4064
3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid
Benzoic acid, 3-[(E)-2-[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]-
GW 4064
(E)-3-(2-chloro-4-((3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl)methoxy)styryl)benzoic acid
3-[(E)-2-(2-Chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methoxy}phenyl)vinyl]benzoic acid
3-(2,6-Dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole
3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoicacid
GW-4064
Biological Activity
[Description]:
[Related Catalog]:
[Target]
EC50: 65 nM (FXR)[1]
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
702.1±60.0 °C at 760 mmHg
[ Molecular Formula ]:
C28H22Cl3NO4
[ Molecular Weight ]:
542.838
[ Flash Point ]:
378.4±32.9 °C
[ Exact Mass ]:
541.061462
[ PSA ]:
72.56000
[ LogP ]:
8.49
[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C
[ Index of Refraction ]:
1.654
[ Storage condition ]:
-20℃
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H319-H413
[ Precautionary Statements ]:
P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22;R36
[ Safety Phrases ]:
S26
[ RIDADR ]:
NONH for all modes of transport
Articles
J. Pharmacol. Exp. Ther. 355 , 429-41, (2015)
Cytosolic sulfotransferase 1C2 (SULT1C2) is expressed in the kidney, stomach, and liver of rats; however, the mechanisms regulating expression of this enzyme are not known. We evaluated transcriptiona...
Circadian control of bile acid synthesis by a KLF15-Fgf15 axis.Nat. Commun. 6 , 7231, (2015)
Circadian control of nutrient availability is critical to efficiently meet the energetic demands of an organism. Production of bile acids (BAs), which facilitate digestion and absorption of nutrients,...
The commonly used antimicrobial additive triclosan is a liver tumor promoter.Proc. Natl. Acad. Sci. U. S. A. 111(48) , 17200-5, (2014)
Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol; TCS] is a synthetic, broad-spectrum antibacterial chemical used in a wide range of consumer products including soaps, cosmetics, therapeutics, and pl...