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Managlinat dialanetil

Names

[ CAS No. ]:
280782-97-0

[ Name ]:
Managlinat dialanetil

[Synonym ]:
MANAGLINAT DIALANETIL/CS-917
ethyl (2S,6S)-4-{5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name)
ethyl 4-[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]-2,6-dimethyl-7-oxo-8-oxa-3,5-d iaza-4-phosphadecan-1-oate 4-oxide
Ethyl (2S,6S)-4-[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide
Managlinat dialanetil
managlinat dialantenil

Biological Activity

[Description]:

Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes[1] [2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[Target]

FBPase[1][2]


[In Vivo]

Managlinat dialanetil dose-dependently inhibits GNG as well as lower basal and postprandial blood glucose levels in Zucker diabetic fatty (ZDF) rats after oral administration[1].

[References]

[1]. Wang Y, et al. Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. Curr Opin Investig Drugs. 2007 Oct;8(10):849-58.

[2]. Wang Y, et al. Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes. Curr Opin Investig Drugs. 2007 Oct;8(10):849-58.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
634.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H33N4O5PS

[ Molecular Weight ]:
500.549

[ Flash Point ]:
337.7±34.3 °C

[ Exact Mass ]:
500.185852

[ PSA ]:
183.83000

[ LogP ]:
2.57

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.552

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds