PBRM1-BD2-IN-6

PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC50 value of 0.22 µM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer[1].

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

IC50: 0.22 nM (PBRM1-BD2)[1]

PBRM1-BD2-IN-6 (compound 25) (0.1, 1, 10 μM; 5 days) shows antiproliferation activity with IC50 values of 0.66, 0.77, 0.32 µM for LNCaP, PC3, HEK293T cells, respectively[1]. Cell Proliferation Assay[1] Cell Line: LNCaP, PC3, HEK293T cells Concentration: 0.1, 1, 10 μM Incubation Time: 5 days Result: Inhibited the cell growth with IC50 values of 0.66, 0.77, 0.32 µM for LNCaP, PC3, HEK293T cells, respectively.