HOOBT

Names

[ Name ]:
HOOBT

[Synonym ]:
HOOBT
EINECS 248-916-1
3-hydroxybenzo[d]1,2,3-triazin-4-one
3-hydroxy-3H-benzo[d][1,2,3]triazin-4-one
1,2,3-Benzotriazin-4(3H)-one, 3-hydroxy-
DHBT
oxohydroxybenzotriazole
4-oxo-3,4-dihydro-3-hydroxy-1,2,3-benzotriazine
3-Hydroxy-1,2,3-benzotriazin-4(3H)-one
3-Hydroxy-4-ketobenzotriazine
3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one
3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine
1,2,3-Benzotriazin-4(3H)-one,3-hydroxy
MFCD00042803
3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine
3-Hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazine

Biological Activity

[Description]:

HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> Anti-infection >> HIV

Research Areas >> Infection

Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

STAT5

[In Vitro]

HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells)[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10)[1]. HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro[1].

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
348.7±25.0 °C at 760 mmHg

[ Melting Point ]:
184-189°C

[ Molecular Formula ]:
C₇H₅N₃O₂

[ Molecular Weight ]:
163.133

[ Flash Point ]:
164.7±23.2 °C

[ Exact Mass ]:
163.038177

[ PSA ]:
68.01000

[ LogP ]:
0.43

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.739

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H312 + H332-H315-H319-H335-H360D

[ Precautionary Statements ]:
P201-P261-P280-P305 + P351 + P338-P308 + P313

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S53-S26-S35-S36/37-S45-S37/39

[ RIDADR ]:
UN 3379 3/PG 1

[ WGK Germany ]:
3

[ Hazard Class ]:
3.0

[ HS Code ]:
2933699090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933699090

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%