STING modulator-3

Names

[ CAS No. ]:
2839639-94-8

[ Name ]:
STING modulator-3

Biological Activity

[Description]:

STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> STING

[In Vitro]

STING modulator-3 (AIP01) (10 μM；3 h，24 h) 分别不影响处理 THP-1 细胞 3 h 时，IRF-3 的磷酸化或是处理 24 h 时，对 TNF-β 的诱导[1]。

[References]

[1]. Gajiwala KS, et al. Imidazole derivatives as STING modulators and their preparation, pharmaceutical compositions and use in the treatment of cancer: World Intellectual Property Organization, WO2022195462. 2022-09-22.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17N9O

[ Molecular Weight ]:
375.39

Related Compounds