MC4033

Names

[ CAS No. ]:
28532-21-0

[ Name ]:
MC4033

Biological Activity

[Description]:

MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1]. MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Signaling Pathways >> Epigenetics >> Histone Acetyltransferase

[Target]

12.1μM (lysine acetyltransferase 8, KAT8)[1]


[References]

[1]. Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616  

Chemical & Physical Properties

[ Molecular Formula ]:
C16H13N3O3

[ Molecular Weight ]:
295.29

Related Compounds